Isotype ControlAPC/Cyanine7 Rat IgG2a, κ Isotype CtrlVerified ReactivityMouseAntibody TypeMonoclonalHost SpeciesRatFormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azidePreparationThe antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.Concentration0.2 mg/mL

Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation LaserRed Laser (633 nm)

• Structure

• Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain

• Distribution

• Eosinophils, alveolar macrophages, intestinal microfold (M) cells

• Function

• Induces apoptosis in eosinophils

• Ligand/Receptor

• [alpha]-2,3-linked sialic acid

• Cell Type

• Eosinophils, Macrophages

• Biology Area

• Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity

• Molecular Family

• CD Molecules, Siglec Molecules

• Antigen References

• 1. Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1.

  2. Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329.

  3. Suzukawa M, et al. 2013. J. Immunol. 190:5939.

  4. Patnode ML, et al. 2013. J. Biol. Chem. 288:26533.